But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. They may be able to help determine whats causing your hair loss. Stopping Zetia treatment shouldnt cause any noticeable side effects. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. POTS-related fatigue is physical in nature . Use of the terms male and female in this article refers to sex assigned at birth. See the Zetia prescribing information for details. Bock's fainting spells are one of the hallmarks of POTS. Your doctor may do liver function tests before you start treatment and regularly during your Zetia treatment. It can be taken with or without fenofibrate in adults. Zetia is FDA-approved to treat certain types of high cholesterol in adults and in children when used with a low-cholesterol diet. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. This is because fenofibrate is the only fibrate Zetia was studied with, so it isnt known whether Zetia and other fibrate drugs are safe to use together. Its not known if its safe to take Zetia while breastfeeding or if the drug passes into breast milk. * Zetia is also approved to treat these conditions in children ages 10 years and older. Brain fog. Zetia belongs to a class of drugs called cholesterol absorption inhibitors. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. Most of Zetias side effects should go away within a few days or weeks. Other side effects not listed may also occur in some patients. Zetia can also be used with statin drugs in adults. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Learn about side effects, dosage, uses, interactions, and more. Youll likely take it once a day. Zetia should be protected from moisture and shouldnt be stored in areas where it could get damp or wet, such as bathrooms. Cholesterol is made naturally in your liver. If you and your doctor determine that Zetia is safe and effective for you, youll likely take it long term. This article provides several useful tips on medication disposal. These drugs havent been directly compared in clinical studies. Statin drugs may pass into breast milk. But keep in mind that Zetia is used to reduce cholesterol levels in your blood. In people with POTS, more blood collects in the lower body when standing upright. Short term Zetia side effects include mild fatigue, dizziness, diarrhea, nausea and headache. Despite having lower total cholesterol than white people, African Americans are at greater risk of dying from heart disease. Ezetimibe may cause side effects. Within 4 to 12 hours of oral administration, a single 10-mg dose of Zetia reaches peak plasma concentrations of 3.4 to 5.5 ng/mL. Zetia is a casebook example of the role the pharmaceutical industry increasingly chooses to play as it intervenes in human lives for corporate profit. Talk with your doctor if you have questions about managing your blood pressure or blood sugar while using Zetia. Side effects could occur in children who are breastfed by someone taking a statin drug. But, they can have side effects and might not be right for you. Zetia is sometimes used with medications in the statin drug class. In most cases, these side effects should be temporary. For this purpose, Zetia may be used: The only FDA-approved dosage of Zetia is 10 mg once a day. If your doctor confirms you had a mild allergic reaction to Zetia, theyll decide if you should continue using it. Zetia may cause mild side effects other than the ones listed above. You can use the study as a second opinion to make health care decisions. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). Crestor is part of the statin drug class. Statin drugs arent safe to use during pregnancy. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older: It isnt known how long adults and children experienced muscle pain while taking Zetia with statin drugs in these clinical studies. Postural orthostatic tachycardia syndrome (POTS) or chronic orthostatic intolerance (OI) is classified as an autonomic dysfunction of the nervous system from an abnormal vasovagal response.. Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Leqvio side effects: What you should know, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 2.4% of people who took a statin drug alone, 2.5% of people who took Zetia with a statin drug, 2.2% of people who took a statin drug alone, 3.2% of adults and children who took Zetia with a statin drug experienced muscle pain, 2.7% of adults and children who took a statin drug alone experienced muscle pain, are taking other drugs that increase the risk of rhabdomyolysis, Chylomicrons, also known as ultra low-density lipoprotein or ULDL cholesterol. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. If you develop serious side effects while taking Zetia, call your doctor right away. Zetia has been found in breast milk during animal studies. Muscle-related problems are a possible side effect of Zetia when used with other medications. Stomach pains were gone after second day. Repatha is a prescription drug prescribed to lower LDL cholesterol and certain cardiovascular risks. Postural orthostatic tachycardia syndrome (POTS) is a blood circulation disorder characterized by two factors: A specific group of symptoms that frequently occur when standing upright. Your risk of developing serious side effects may increase if you take Zetia with other medications to treat high cholesterol, such as statin drugs. Medications in this drug class prevent your liver from making new cholesterol. Recently, POTS has been diagnosed in some people who have had COVID-19. This in turn increases clearance of cholesterol from the blood. No, hair loss isnt a known side effect of Zetia. It's Aimee Esther here! It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. Before taking Zetia, talk with your doctor about your health history. Zinnia elegans 'Benary's Giant Golden Yellow'. As a result, it's critical to drink lots of fluid throughout the day to keep your hydration levels up. Then theyll monitor whether the drug is working for you and whether you experience any side effects. Like most drugs, Zetia can cause an allergic reaction in some people. Statins are another type of medication used to lower cholesterol. If you develop liver problems, you may be more likely to experience side effects with Zetia. If you develop increased liver enzyme levels, your doctor may make changes to your treatment plan. Its intestinal molecular target is the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter. Symptoms of liver damage include: If you have any of the above symptoms of liver damage, tell your doctor right away. Generics tend to cost less than brand-name drugs. Zetia can cause certain side effects, some of which are more common than others. The absence of symptoms doesn't necessarily mean that the cause of POTS is gone as well. You may not have any symptoms of gallstones unless they cause your gallbladder to swell. Fenofibrate is a drug used to lower your triglyceride levels. The actual price youll pay for any of these drugs depends on your insurance plan, your location, and the pharmacy you use. Other drugs are available that can treat your conditions. This is because it isnt safe to eat grapefruit or drink grapefruit juice while using a statin. But in studies, some people had to stop taking the drug due to feeling dizzy. Zetia and Crestor are both brand-name drugs. No, clinical studies havent shown Zetia to affect blood pressure. Uses. If you develop bothersome muscle pain or other muscle-related symptoms, talk with your doctor. In these groups, joint pain occurred in: The length of time that adults and children experienced joint pain while taking Zetia in these clinical studies isnt known. This date is typically 1 year from the date they dispensed the medication. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. Ask your doctor what other medications are better options for you. Plant sterols are similar to cholesterol. While there's no cure, several treatments and lifestyle changes can help manage the symptoms of POTS. The phase IV clinical study analyzes which people take Zetia and have Constipation. The insurance company will review the prior authorization request and decide if the drug will be covered. If you would like to report to the FDA a side effect youve had with Zetia, you can do so through MedWatch. Crossing your legs in front of each other while standing, rocking up and down on your toes. Zetia is meant to be used as a long-term treatment. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. It isnt safe to eat grapefruit or drink grapefruit juice while using statins. Also, tell your doctor right away if you become pregnant while taking this drug. Since every POTS patient is different, some may primarily experience gastrointestinal symptoms, such as nausea, vomiting or poor feeding, Berger explained. During Zetia treatment, your doctor will likely recommend blood tests. You may also be having a reaction to all the medications mixed together. 1. They can tell you about other medications that may work well for you. Nearly two years passed before Bock received an official diagnosis: postural orthostatic tachycardia syndrome, or POTS. joint or muscle pain*. (A class of drugs is a group of medications that work in a similar way.) Statins are commonly prescribed with Zetia to treat certain types of high cholesterol. Its not known how many adults and children experienced muscle pain in clinical studies of other conditions treated with Zetia and statin drugs. For more information, see the How Zetia works section below. Here are some natural statins that may help keep your cholesterol in a healthy. Serious side effects from Zetia arent common, but they can occur. For example, in studies, some people had to stop taking the drug because their liver enzyme levels increased. If youre concerned about joint pain while using Zetia, talk with your doctor. Tramadol will usually cause a blistering type rash with itching which you do not describe. Clinical studies involved adults and children ages 10 years and older. Lipitor ( atorvastatin) and Zetia ( ezetimibe) are used to lower cholesterol levels in the blood. If you have liver problems, your liver may not work properly to remove medications such as Zetia from your body. There are no known interactions between Zetia and alcohol. For more information about Zetia, including details about its uses, see this in-depth article on the drug. Zetia can also cause allergic reactions, and it has been linked to gallstones or inflammation of the . For some drugs, doing so may lead to unwanted side effects or overdose. This means you should avoid foods that are high in cholesterol and other types of fat. Lipitor contains the active drug atorvastatin. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. When you get Zetia from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. Zetia generally costs less than Lipitor. POTS is commonly associated with low levels of fluid. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. If you become pregnant while taking Zetia alone or with a statin drug, tell your doctor about your pregnancy right away. Read on to find out more about healthy cholesterol levels, and if a cholesterol level of 250 ml/dL is considered, Heart disease is a top cause of death in the U.S. We talked to experts about, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Ways to reduce the symptoms. Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. Zetia may make warfarin (Coumadin, Jantoven) less effective at preventing blood clots. It also isnt known how many adults and children experienced joint pain in clinical studies of Zetia used to treat other conditions. The generic is considered to be as safe and effective as the original drug. Read More. Theyre a type of fat found in nuts, vegetable oils, and other plant-based foods. And taking it with Zetia and a statin likely wont cause any problems. Chylomicrons help your body, low-density lipoproteins (LDL), sometimes referred to as bad cholesterol, high-density lipoproteins (HDL), sometimes referred to as good cholesterol, triglycerides, which are a type of fat that are building blocks of cholesterol, Apo B (high levels of this protein are a sign of high cholesterol), non-HDL cholesterol (calculated by subtracting your HDL cholesterol level from your total cholesterol), were reduced by an average of 13% to 14% in people who used Zetia, ranged from not changing to being reduced by an average of 1% in people who used a placebo, were reduced by an average of 18% in people who used Zetia, increased by an average of 1% in people who used a placebo, decreased by an average of 13% to 14% in people who used Zetia alone, decreased by an average of 15% to 40% in people who used a statin alone, depending on the statin used, decreased by an average of 24% to 46% in people who used Zetia and a statin, depending on the statin used, ranged from decreasing by an average to 1% to increasing by an average of 4% in people who took a placebo, decreased by an average of 19% to 20% in people who used Zetia alone, decreased by an average of 20% to 54% in people who used a statin alone, depending on the statin used, decreased by an average of 34% to 61% in people who used Zetia and a statin, depending on the statin used. Here are a few questions to get your discussion started with your doctor: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. A Mayo Clinic study published this month in Pacing and Electrophysiology (PACE), suggests that a class of medications more commonly prescribed for older adults is a strong first-line treatment for teenagers with a debilitating condition called postural orthostatic tachycardia syndrome, or POTS. Talk with your doctor about birth control options that may be best for you. Talk with your doctor if youre concerned about your risk of memory loss while using Zetia alone or with a statin drug. If you no longer need to take Zetia and have leftover medication, its important to dispose of it safely. They often originate at the base of the skull and spreading on the back of the head and neck. Youll likely take Zetia once a day. These problems can include muscle pain and muscle weakness, and rarely, muscle breakdown. We avoid using tertiary references. Study on Ezetimibe Yielded Disappointing Results: Another reader wrote us shortly after learning of the results of a study that raised questions about ezetimibe: Q. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. Fatigue. However, it isnt known how Zetia may affect these risks. Statins lower cholesterol by preventing your liver from making new cholesterol. But its possible that some side effects may continue to affect you for as long as youre taking the medication. Temporary excursions of 59F to 86F (15C to 30C) are allowed. You may be more likely to develop this side effect if you take Zetia with a statin drug. Zetia (ezetimibe) is a prescription drug that treats high cholesterol in adults and children. The list below includes factors to consider. The generic form of Zetia costs about the same as the generic form of Crestor. As patients we need to be constantly wary because it is increasingly clear that the pharmas have abrogated their responsibility on our behalf. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. Risk factors for muscle-related problems. Here are answers to some frequently asked questions about Zetia. POTS is defined by its particular symptoms and an excessive increase in heart rate upon standing. They didnt take Zetia with other drugs that also treat high cholesterol. Postural orthostatic tachycardia syndrome (POTS) is a condition characterized by lightheadedness or dizziness when standing and a racing heart. A large review by the American Heart Association compared studies of CoQ10. However, excessive alcohol use can damage your liver over time. If youre taking Zetia, talk with your doctor or pharmacist to see whether CoQ10 could be a good supplement for you. When this happens, more cholesterol can then be cleared from your blood by your liver. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. fainting (passing out) problems with thinking, memory and concentration - this combination of symptoms is often called 'brain fog'. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. The Benary's Giants have large, double blossoms, 4 to 6 inches across, available in a rainbow of . Learn how we can help. You can learn more about how we ensure our content is accurate and current by reading our. This is not a complete list of side effects and others may occur. Below are medications that can interact with Zetia. For mixed high cholesterol, Zetia is FDA-approved to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet and is taken with other drugs. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone. Taking Zetia with a statin may cause this side effect. Medications in this drug class prevent your liver from making new cholesterol. Depending on your age or other medical conditions you may have, you may be at higher risk of developing rhabdomyolysis while taking Zetia. Zetia comes as a tablet that you swallow. Learn about the common, mild, and serious side effects it can cause and how to manage them. Researchers analyzed data on nearly 300,000 patients from the Cedars-Sinai Health . They can both be taken with or without food. These side effects may be temporary, lasting a few days to weeks. Dizziness is a rare side effect of taking Zetia. The heart beats faster to pump it up to the brain, but with little success. Zetia may not be right for you if you have certain medical conditions or other factors affecting your health. Statins, another medication for high cholesterol, are known to cause muscle-related side effects. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about . Zetia may also increase the amount of cholesterol thats stored in your gallbladder. Allergic reaction. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. If left untreated, it can cause your kidneys to stop working properly. Crestor contains the active drug rosuvastatin. Zetia is metabolized in the small intestine and liver. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. Clinical studies looked at Zetia for the treatment of primary hyperlipidemia in adults and in children ages 10 years and older. Examples of other drugs that may be used to treat primary high cholesterol include: Examples of other drugs that may be used to treat mixed high cholesterol include: Examples of other drugs that may be used to treat homozygous familial hypercholesterolemia include: Examples of other drugs that may be used to treat homozygous sitosterolemia include: You may wonder how Zetia compares with other medications that are prescribed for similar uses. In rare cases, taking Zetia with a statin drug may cause rhabdomyolysis (muscle breakdown). In fact, researchers have looked into using Zetia to treat hair loss due to a condition called alopecia areata. If your doctor confirms you had a serious allergic reaction to Zetia, they may have you switch to a different treatment. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). Symptoms of a swollen gallbladder may include: Tell your doctor if you experience gallstones while using Zetia with fenofibrate. (A class of drugs is a group of medications that work in a similar way.) You can take Zetia with or without food. They can recommend treatments that may help with joint pain, or they may recommend a different treatment option for you. For information on the effectiveness of Zetia, see the Zetia uses section below. Have your doctor measure your heart rate sitting and standing. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. But new medications can help lower cholesterol and improve heart health. It can develop suddenly or maybe over time. If youre using Zetia while sexually active with a female who could become pregnant, talk with your doctor about your birth control needs. Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). Read more about these alternatives to traditional statin, Having high cholesterol puts you at risk for a heart attack or stroke. Grapefruit can prevent the breakdown of these drugs in your body. Cholesterol is a fatty substance found in the cells of your body. And some may be easily managed, too. For more information about how the drug is used, see the Zetia uses section below. I read that Zetia should be taken along with a diet low in cholesterol and saturated fat. Learn about the drugs dosages, forms, strengths, and more. Nausea/Vomiting. zetia. Talk with your doctor about your health history before you take Zetia. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Zetia is a brand-name prescription drug. The generic form of Zetia costs about the same as the generic form of Lipitor. However, 0.3% of people who took Zetia alone experienced joint pain so bothersome that they had to stop treatment. Therefore, you shouldnt breastfeed if youre taking Zetia with a statin drug. The heartbeat increases with a feeling of the heart fluttering. If your muscle-related side effects dont go away or become severe, tell your doctor right away. (For more information on the specific conditions Zetia can treat, see the Zetia uses section.). (For information on side effects, see the Zetia side effects section above.). The generic is considered to be as safe and effective as the original drug. It isnt known how often this side effect occurred with Zetia in clinical studies. MS: Can the Mediterranean diet help preserve cognitive health? Zetias side effects are usually mild, especially if youre taking Zetia alone. But if they become more severe or dont go away, talk with your doctor or pharmacist. Merck, the manufacturer of Zetia, offers a Patient Assistance Program. Drugs in this class prevent your small intestine from absorbing cholesterol. During your Zetia treatment, consider keeping notes on any side effects youre having. No, stopping Zetia shouldnt cause any side effects. Zetias mechanism of action is considered complementary to that of statins and fenofibrate. Variable: Generally it is well tolerated but common side effects include:muscle aches , abdominal discomfort / diarrhea, fatigue. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. These conditions can raise your risk of muscle problems while taking Zetia. More common side effects in people taking Zetia* include: * In studies, these side effects were reported in people who took Zetia by itself. Side effects may be more likely in older adults. An allergic reaction is possible after using Zetia. A generic drug is an exact copy of the active drug in a brand-name medication. This is because large meals can cause blood to pool excessively in the abdomen. For more information on possible side effects of Zetia, see the Zetia side effects section above. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. People with this condition have high levels of LDL (bad) cholesterol, high levels of triglycerides, and low levels of HDL (good) cholesterol. This active drug is also available as a generic medication. For more information and to find out if youre eligible for support, call 800-727-5400 or visit the program website. If you feel dizzy from Zetia, it may help to take your dose at bedtime. They are caused by deficiencies in enzymes involved in the synthesis of heme. (A class of medications is a group of drugs that work in a similar way.) They can suggest ways to help relieve your side effects, or they may recommend a different treatment option for you. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. Some people with POTS also may have one or more . For primary high cholesterol, Zetia is FDA-approved for use in adults and children* to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet. Cholesterol itself isnt a harmful substance. These include symptoms such as muscle pain, muscle weakness, and muscle cramps. This can cause gallstones (hardened stones in your gallbladder). Medications in the fibrate drug class are used to treat high cholesterol. Talk with your doctor if you experience diarrhea while taking this medication. Additionally, a change in weight is not a listed side . Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . The symptoms develop immediately and include dizziness and an intense headache. If you and your doctor decide that Zetia treatment isnt right for you, you simply wont take any more doses. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Lipitor, or with both drugs (when taken individually). Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. Ezetimibe can cause the breakdown of muscle tissue . (A drug class is a group of medications that work in a similar way.) Symptoms develop immediately and include dizziness and an excessive increase in heart rate sitting and.. At higher risk of dying from heart disease: the only FDA-approved dosage Zetia... Statins are another type of medication used to reduce cholesterol levels in your body with itching you! Enzyme levels increased but if they become more severe allergic reaction to Provochol with muscle. Your toes statin drug class prevent your liver from making new cholesterol to feeling dizzy hydrocortisone cream information, this! 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